Phospho-ablation of cardiac sodium channel Na v 1.5 mitigates susceptibility to atrial fibrillation and improves glucose homeostasis under conditions of diet-induced obesity

• Published in: International journal of obesity (2005) Vol. 45; no. 4; p. 795
• Main Authors: Dewal, Revati S, Greer-Short, Amara, Lane, Cemantha, Nirengi, Shinsuke, Manzano, Pedro Acosta, Hernández-Saavedra, Diego, Wright, Katherine R, Nassal, Drew, Baer, Lisa A, Mohler, Peter J, Hund, Thomas J, Stanford, Kristin I
• Format: Journal Article
• Language: English
• Published: England 01.04.2021
• Subjects: Animals; Atrial Fibrillation - prevention & control; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism; Diet, High-Fat - adverse effects; Gene Knock-In Techniques; Glucose - metabolism; Homeostasis; Male; Mexiletine - pharmacology; Mice; Mice, Inbred C57BL; NAV1.5 Voltage-Gated Sodium Channel - genetics; NAV1.5 Voltage-Gated Sodium Channel - metabolism; Obesity - physiopathology; Phosphorylation

Atrial fibrillation (AF) is the most common sustained arrhythmia, with growing evidence identifying obesity as an important risk factor for the development of AF. Although defective atrial myocyte excitability due to stress-induced remodeling of ion channels is commonly observed in the setting of AF...