MtcB, a member of the MttB superfamily from the human gut acetogen Eubacterium limosum, is a cobalamin-dependent carnitine demethylase

• Published in: The Journal of biological chemistry Vol. 295; no. 34; p. 11971
• Main Authors: Kountz, Duncan J, Behrman, Edward J, Zhang, Liwen, Krzycki, Joseph A
• Format: Journal Article
• Language: English
• Published: United States 21.08.2020
• Subjects: acetogenesis; bacterial metabolism; folate; cobalamin; microbiology; carnitine; enzyme catalysis; microbiome; energy metabolism; one-carbon metabolism

The trimethylamine methyltransferase MttB is the first described member of a superfamily comprising thousands of microbial proteins. Most members of the MttB superfamily are encoded by genes that lack the codon for pyrrolysine characteristic of trimethylamine methyltransferases, raising questions ab...