Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum

• Published in: Molecular & cellular proteomics Vol. 19; no. 2; p. 308
• Main Authors: Birrell, Geoffrey W, Challis, Matthew P, De Paoli, Amanda, Anderson, Dovile, Devine, Shane M, Heffernan, Gavin D, Jacobus, David P, Edstein, Michael D, Siddiqui, Ghizal, Creek, Darren J
• Format: Journal Article
• Language: English
• Published: United States 01.02.2020
• Subjects: Metabolomics; antimalarial drug discovery; mode of action; proteomics; peptidomics; 2-aminomethylphenol; drug targets; malaria; metabolites

The increasing incidence of antimalarial drug resistance to the first-line artemisinin combination therapies underpins an urgent need for new antimalarial drugs, ideally with a novel mode of action. The recently developed 2-aminomethylphenol, JPC-3210, (MMV 892646) is an erythrocytic schizonticide w...