Surgical results and the location of pathological glands in the treatment of primary sporadic hyperparathyroidism with negative preoperative 99m Tc-sestamibi scintigraphy

• Published in: Cirugia española (English ed.)
• Main Authors: Agirre, Leire, de la Quintana, Aitor, Martínez, Gloria, Arana, Ainhoa, Servide, María José, Larrea, Jasone
• Format: Journal Article
• Language: English
• Published: Spain 18.12.2020
• Subjects: Cure; Localización de adenoma; Curación; Hiperparatiroidismo primario; Primary hyperparathyroidism; Adenoma location; Negative sestamibi scintigraphy; Gammagrafía MIBI negativa

The primary hyperparathyroidism is a frequent disease whom the surgery is the only curative treatment. The preoperative location imaging techniques could help in the surgical management. Our objective was to analyze surgical results regarding the cure rate, etiology and location of the glands responsible for the primary hyperparathyroidism in patients with negative preoperative Tc-sestamibi scintigraphy. Observational study in patients with the diagnosis of primary sporadic hyperparathyroidism with negative Tc-sestamibi scintigraphy, operated consecutively in an Endocrine Surgery Unit for 18 years. The cure rate, the intraoperatory parathyroid hormone (PTH), the etiology and the pathological glands location were analyzed. In the study were included 120 patients. After surgery 95% of patients (n = 114) presented cure criteria of hyperparathyroidism. The 14.1% presented a multigland disease; 69% of the adenomas presented a typical perithyroid location, founding a percentage of 23.9% of ectopic adenomas in cervical location and a 7.1% in mediastinum. The absence of uptake in the Tc-sestamibi scintigraphy should not condition the surgical indication. The success with experienced surgeons is similar to patients with positive results. The surgical indication must be established by clinical and biochemistry criteria.