Aspartic acid 70 in the HLA-DRB1 chain and shared epitope alleles partially explain the high prevalence of autoimmunity in Mexicans

• Published in: Journal of translational autoimmunity (Online) Vol. 3; p. 100057
• Main Authors: Valdés-Corona, Luis Francisco, Hernández-Doño, Susana, Rodríguez-Reyna, Tatiana Sofia, García-Silva, Rafael, Jakez, Juan, Escamilla-Tilch, Monica, Lima, Guadalupe, Llorente, Luis, Pineda, Carlos, Yunis, Edmond, Granados, Julio
• Format: Journal Article
• Language: English
• Published: Netherlands 2020
• Subjects: Hashimoto’s disease; Shared epitope; Graves’ disease; Rheumatoid arthritis; Multiple autoimmunities; Autoimmune thyroid disease; HLA-DRB1

Autoimmune thyroid disease (AITD) is the most common autoimmune disorder worldwide. Remarkably, it is commonly accompanied by other autoimmune diseases, such as rheumatoid arthritis (RA). The immunopathogenic mechanisms behind the coexistence of these disorders are still not completely understood. I...