Efficacy of Gefitinib Combined with 125 I Radioactive Particles in the Treatment of Transplanted Lung Cancer Tumors in Nude Mice

• Published in: Cardiovascular and interventional radiology Vol. 43; no. 9; p. 1364
• Main Authors: Li, Chaojie, Yao, Linyan, Gong, Ju, Pang, Haopeng, Shan, Qungang, Wang, Ziyin, Lu, Jian, Wang, Zhongmin
• Format: Journal Article
• Language: English
• Published: United States 01.09.2020
• Subjects: Adenocarcinoma of Lung - therapy; Animals; Antineoplastic Agents - therapeutic use; Cell Line, Tumor; Female; Gefitinib - therapeutic use; Iodine Radioisotopes - therapeutic use; Lung - pathology; Lung Neoplasms - pathology; Lung Neoplasms - therapy; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; 18fluorine-fluorinedeoxyglucose (18F-FDG); 125I radioactive particles; Biofluorescence imaging; Lung adenocarcinoma; Gefitinib

To investigate the efficacy of gefitinib combined with iodine-125 ( I) radioactive particles in the treatment of transplanted tumors of the lung cancer cell line A549 in nude mice. Twenty-four nude mice were inoculated with A549-luc human lung adenocarcinoma cells stably expressing luciferase. The t...