m 5 C modification of mRNA serves a DNA damage code to promote homologous recombination

• Published in: Nature communications Vol. 11; no. 1; p. 2834
• Main Authors: Chen, Hao, Yang, Haibo, Zhu, Xiaolan, Yadav, Tribhuwan, Ouyang, Jian, Truesdell, Samuel S, Tan, Jun, Wang, Yumin, Duan, Meihan, Wei, Leizhen, Zou, Lee, Levine, Arthur S, Vasudevan, Shobha, Lan, Li
• Format: Journal Article
• Language: English
• Published: England 05.06.2020
• Subjects: Animals; Cell Line, Tumor; Cytosine - metabolism; DNA (Cytosine-5-)-Methyltransferases - genetics; DNA (Cytosine-5-)-Methyltransferases - metabolism; DNA Breaks, Double-Stranded; Drug Resistance, Neoplasm - genetics; Gene Knockdown Techniques; Homologous Recombination; Humans; Methylation; Mice; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; Poly(ADP-ribose) Polymerase Inhibitors - pharmacology; Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use; Rad51 Recombinase - metabolism; Rad52 DNA Repair and Recombination Protein - metabolism; RNA Processing, Post-Transcriptional - genetics; RNA, Messenger - metabolism; RNA, Small Interfering - metabolism; Xenograft Model Antitumor Assays

Recruitment of DNA repair proteins to DNA damage sites is a critical step for DNA repair. Post-translational modifications of proteins at DNA damage sites serve as DNA damage codes to recruit specific DNA repair factors. Here, we show that mRNA is locally modified by m C at sites of DNA damage. The...