Zn 2+ and mPTP mediate resveratrol-induced myocardial protection from endoplasmic reticulum stress

• Published in: Metallomics Vol. 12; no. 2; p. 290
• Main Authors: He, Yifei, Fu, Yu, Xi, Mengyao, Zheng, Huan, Zhang, Yidong, Liu, Yulin, Zhao, Yang, Xi, Jinkun, He, Yonggui
• Format: Journal Article
• Language: English
• Published: England 26.02.2020
• Subjects: Animals; Cardiotonic Agents - pharmacology; Cell Line; Chromones - metabolism; Endoplasmic Reticulum Stress - radiation effects; Glycogen Synthase Kinase 3 beta - metabolism; Mitochondrial Permeability Transition Pore - metabolism; Morpholines - metabolism; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; Rats; Resveratrol - pharmacology; Signal Transduction; Zinc - metabolism

Resveratrol displays cardioprotective activity; however, its mechanism of action remains unclear. In the current study, resveratrol-induced myocardial protection from endoplasmic reticulum stress (ERS) was investigated, focusing on the roles of Zn2+ and the mitochondrial permeability transition pore...