Risk factors for recurrence of laryngeal amyloidosis treated by microforceps and CO 2 laser

• Published in: European archives of oto-rhino-laryngology Vol. 277; no. 2; p. 521
• Main Authors: Wu, Xiufa, Zhang, Jing, Wei, Chunsheng
• Format: Journal Article
• Language: English
• Published: Germany 01.02.2020
• Subjects: Adult; Amyloidosis - diagnosis; Amyloidosis - surgery; Female; Humans; Laryngeal Diseases - diagnosis; Laryngeal Diseases - surgery; Larynx - surgery; Laser Therapy; Lasers, Gas - therapeutic use; Male; Microsurgery; Middle Aged; Recurrence; Retrospective Studies; Risk Factors; Young Adult; Recurrence; Treatment; Duration from onset to the treatment; Laryngeal amyloidosis; Hoarseness; Selection and timing of operation

Laryngeal amyloidosis is a benign, slowly progressive disease. The factors affecting the recurrence of LA have not been studied before for the rarity and incomplete understanding of this disease. To investigate the risk factors for the laryngeal amyloidosis treated by microforceps or carbon dioxide laser under microlaryngoscope, a retrospective review was conducted. One hundred and four patients (42 male and 72 female, with an average age of 51.3 years) with laryngeal amyloidosis were identified. The cases were collected from January 1989 to May 2014 at the Eye, Ear, Nose, and Throat Hospital of Fudan University. Seventy-five patients complained of hoarseness, 36 patients complained of hoarseness and dyspnea, and 3 patients complained of foreign body sensation. All patients underwent surgical removal of the amyloid deposits (via microforceps, CO laser and tracheotomy). Thirty patients developed recurrences requiring further treatments. The duration from onset to the treatment and age affected the recurrence of laryngeal amyloidosis, the surgery method, stenotic degree and stenotic area of subglottic area and trachea did not affect the recurrence of the disease. Early diagnosis and treatment of laryngeal amyloidosis may reduce the recurrence of the disease. Regular follow-up is necessary to find any recurrence.