A Review of PCSK9 Inhibitors and their effects on cardiovascular disease

• Published in: Current topics in medicinal chemistry
• Main Authors: Chen, Bo, Zhao, Pengjun, Shi, Xin, Cui, Yanping, Hou, Aiping
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 08.08.2019
• Subjects: hypercholesterolemiProprotein convertase subtilisin/kexin type 9 (PCSK9); inhibitors; clinical effect; Proprotein convertase subtilisin/kexin type 9 (PCSK9); pharmacokinetic; hypercholesterolemia; pharmacodynamic profile

Cardiovascular disease remains the leading cause of morbidity and mortality in the world, with elevated low density lipoprotein-cholesterol (LDL-C) levels as a major risk factor. Lower levels of LDL-C can effectively reduce the risk of cardiovascular disease. Proprotein convertase subtilisin/kexin t...