Involvement of 5-HT 1A/1B receptors in the antinociceptive effect of paracetamol in the rat formalin test

• Published in: Neurobiology of pain Vol. 3; p. 15
• Main Authors: Roca-Vinardell, A, Berrocoso, E, Llorca-Torralba, M, García-Partida, J A, Gibert-Rahola, J, Mico, J A
• Format: Journal Article
• Language: English
• Published: United States 01.01.2018
• Subjects: Paracetamol; 5-HT1B receptors; Antinociceptive effect; 5-HT1A receptors; Formalin test

The mechanism of analgesic action of paracetamol (acetominophen) remains still unknown. However, a relationship between serotonergic system and the effect of paracetamol has been previously demonstrated. The serotonin activity in the brainstem is primarily under the control of 5-HT somatodendritic r...