Post-Synthetic Ligand Exchange of Metal Organic Framework for Photodynamic Therapy
Attributed to the large pore size and excellent stability, the metal organic framework (MOF) NU-1000, which is formed by the coordination of Zr cluster and 1,3,6,8-tetrakis(p-benzoicacid)pyrene (H4TBAPy) ligand, has been widely studied in the catalysis research field, however, only a few reports abo...
Saved in:
Published in | ACS applied materials & interfaces |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
30.01.2019
|
Online Access | Get full text |
Cover
Loading…
Abstract | Attributed to the large pore size and excellent stability, the metal organic framework (MOF) NU-1000, which is formed by the coordination of Zr cluster and 1,3,6,8-tetrakis(p-benzoicacid)pyrene (H4TBAPy) ligand, has been widely studied in the catalysis research field, however, only a few reports about the biomedical application of NU-1000 could be found in the open literature. In this study, a functional ligand, tetrakis(4-carboxyphenyl)porphyrin (TCPP) was introduced into NU-1000 via post-synthetic ligand exchange method, and the resultant mixed ligand MOF possesses excellent photodynamic effect. Finally, in vitro and in vivo assessment about the antitumor efficacy was investigated for the first time. It demonstrates the feasibility of TCPP substituted NU-1000 to be used for photodynamic therapy, and also provides an alternative approach to enrich the function of MOF for various applications via post-synthetic method. |
---|---|
AbstractList | Attributed to the large pore size and excellent stability, the metal organic framework (MOF) NU-1000, which is formed by the coordination of Zr cluster and 1,3,6,8-tetrakis(p-benzoicacid)pyrene (H4TBAPy) ligand, has been widely studied in the catalysis research field, however, only a few reports about the biomedical application of NU-1000 could be found in the open literature. In this study, a functional ligand, tetrakis(4-carboxyphenyl)porphyrin (TCPP) was introduced into NU-1000 via post-synthetic ligand exchange method, and the resultant mixed ligand MOF possesses excellent photodynamic effect. Finally, in vitro and in vivo assessment about the antitumor efficacy was investigated for the first time. It demonstrates the feasibility of TCPP substituted NU-1000 to be used for photodynamic therapy, and also provides an alternative approach to enrich the function of MOF for various applications via post-synthetic method. |
Author | Sun, Chunqiang Ding, Binbin Pang, Maolin Cai, Xuechao Zhao, Xueyan Liu, Guofeng Zhang, Zhixiang Hu, Chunling Shao, Shuai |
Author_xml | – sequence: 1 givenname: Xueyan surname: Zhao fullname: Zhao, Xueyan – sequence: 2 givenname: Zhixiang surname: Zhang fullname: Zhang, Zhixiang – sequence: 3 givenname: Xuechao surname: Cai fullname: Cai, Xuechao – sequence: 4 givenname: Binbin surname: Ding fullname: Ding, Binbin – sequence: 5 givenname: Chunqiang surname: Sun fullname: Sun, Chunqiang – sequence: 6 givenname: Guofeng surname: Liu fullname: Liu, Guofeng – sequence: 7 givenname: Chunling surname: Hu fullname: Hu, Chunling – sequence: 8 givenname: Shuai surname: Shao fullname: Shao, Shuai – sequence: 9 givenname: Maolin surname: Pang fullname: Pang, Maolin |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30698413$$D View this record in MEDLINE/PubMed |
BookMark | eNqFjjEOgjAAABujEVG_YPoBkkKBwGwgDhqJspMKhaK0JW2N9vcy6Ox0w91wLpgLKegMrPw0DL0kiAIHuFrfEYpxgKIlcDCK0yT08QpcCqmNd7XCMGr6Gh77jogGZu-aEdFRKFt4ooYM8KwmMQW5Ipy-pHrAVipYMGlkYwXhkyoZVWS0G7BoyaDp9ss12OVZuT944_PGaVONqudE2eo3gf8GH5CiPrU |
ContentType | Journal Article |
DBID | NPM |
DatabaseName | PubMed |
DatabaseTitle | PubMed |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Engineering |
EISSN | 1944-8252 |
ExternalDocumentID | 30698413 |
Genre | Journal Article |
GroupedDBID | --- .K2 23M 4.4 53G 55A 5GY 5VS 5ZA 6J9 7~N AABXI AAHBH ABJNI ABMVS ABQRX ABUCX ACGFS ACS ADHLV AEESW AENEX AFEFF AHGAQ ALMA_UNASSIGNED_HOLDINGS AQSVZ BAANH CUPRZ EBS ED~ EJD F5P GGK GNL IH9 JG~ NPM P2P RNS ROL UI2 VF5 VG9 W1F XKZ |
ID | FETCH-pubmed_primary_306984133 |
IngestDate | Sat Sep 28 08:39:33 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-pubmed_primary_306984133 |
PMID | 30698413 |
ParticipantIDs | pubmed_primary_30698413 |
PublicationCentury | 2000 |
PublicationDate | 2019-Jan-30 |
PublicationDateYYYYMMDD | 2019-01-30 |
PublicationDate_xml | – month: 01 year: 2019 text: 2019-Jan-30 day: 30 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | ACS applied materials & interfaces |
PublicationTitleAlternate | ACS Appl Mater Interfaces |
PublicationYear | 2019 |
SSID | ssj0063205 |
Score | 4.202837 |
Snippet | Attributed to the large pore size and excellent stability, the metal organic framework (MOF) NU-1000, which is formed by the coordination of Zr cluster and... |
SourceID | pubmed |
SourceType | Index Database |
Title | Post-Synthetic Ligand Exchange of Metal Organic Framework for Photodynamic Therapy |
URI | https://www.ncbi.nlm.nih.gov/pubmed/30698413 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ1LS8NAEMcX25MexPe77MGbRMzu5nXUUimiIrZC8VI2adLmYFJKCq2f3tlXEosF9bKEJIRNfsvu7GT-Mwhdgg0w8uzQsxisptAQ1woiJ7BGBFar2Oe2nwg18tOz231jDwNnUNXWk-qSIryOPn_UlfyHKpwDrkIl-wey5UPhBBwDX2iBMLS_Yiwq7Vq9ZQZGnMi7-piOhRu8s1BqXhndEguxoxJcRsJKVZFYMrjwZZIX-UhVpBeRF2V2AZOUtt274tpIBbtWvZAcKiLHxCwRwVw1v7P0uQ7m8bIab6U3-n2SLmAcjqs_Hqm-G7qal8a0rq9yl2ahTgiu_RFCAmWbXyuxmkMDxizYeJL6DA0fbvohMcAeJfCZEqCupLo2lxqoQW0RnwkvapZVl5IbUWbI3LOyDZDmQH8HbWs7Ht8qKLtoI8720FYtu-M-ev2OBys82ODBeYIlHqzx4BIPBjy4jgdrPAeodd_pt7uW6tRwqnKFDE136SFqZnkWHyMM0yblLkuciIbMIZz71HO4SxJuUxL47gk6WvOQ07VXztBmxeIcNYvZPL4Aa6kIW_IrfgEOYx30 |
link.rule.ids | 315,786,790 |
linkProvider | American Chemical Society |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Post-Synthetic+Ligand+Exchange+of+Metal+Organic+Framework+for+Photodynamic+Therapy&rft.jtitle=ACS+applied+materials+%26+interfaces&rft.au=Zhao%2C+Xueyan&rft.au=Zhang%2C+Zhixiang&rft.au=Cai%2C+Xuechao&rft.au=Ding%2C+Binbin&rft.date=2019-01-30&rft.eissn=1944-8252&rft_id=info%3Apmid%2F30698413&rft.externalDocID=30698413 |