High toxicity of Bi(OH) 3 and α-Bi 2 O 3 nanoparticles towards malignant 9L and MCF-7 cells

• Published in: Materials science & engineering. C, Materials for biological applications Vol. 93; p. 958
• Main Authors: Bogusz, K, Tehei, M, Cardillo, D, Lerch, M, Rosenfeld, A, Dou, S X, Liu, H K, Konstantinov, K
• Format: Journal Article
• Language: English
• Published: Netherlands 01.12.2018
• Subjects: Animals; Apoptosis - drug effects; Bismuth - chemistry; Bismuth - pharmacology; Cytotoxins - chemistry; Cytotoxins - pharmacology; Dogs; Drug Screening Assays, Antitumor; Female; Humans; Madin Darby Canine Kidney Cells; MCF-7 Cells; Nanoparticles; Nanoparticles; Reactive oxygen species; Bi(OH); Cancer therapy; BiO

Here we report the extreme toxicity in vitro of Bi(OH) and α-Bi O nanoparticles (NPs), obtained through a facile synthesis with an average single particle size of 6-10 nm, tested on malignant gliosarcoma 9L and MCF-7 human breast cancer cells. For both nanomaterials, clonogenic assays reveal a morta...