Malic Enzyme 1 (ME1) is pro-oncogenic in Apc Min/+ mice

• Published in: Scientific reports Vol. 8; no. 1; p. 14268
• Main Authors: Fernandes, Lorenzo M, Al-Dwairi, Ahmed, Simmen, Rosalia C M, Marji, Meera, Brown, Dustin M, Jewell, Sarah W, Simmen, Frank A
• Format: Journal Article
• Language: English
• Published: England 24.09.2018
• Subjects: Adenomatous Polyposis Coli Protein - genetics; Animals; Carcinogenesis - genetics; Cell Proliferation - genetics; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; DNA-Binding Proteins - genetics; Epithelial Cells - metabolism; Epithelial Cells - pathology; Gastrointestinal Tract - metabolism; Gastrointestinal Tract - pathology; Gene Expression Regulation, Neoplastic - genetics; Humans; Intestinal Mucosa; Malate Dehydrogenase - antagonists & inhibitors; Malate Dehydrogenase - genetics; Mice; Oncogenes; Rats; Transcription Factors - genetics

Cytosolic Malic Enzyme (ME1) provides reduced NADP for anabolism and maintenance of redox status. To examine the role of ME1 in tumor genesis of the gastrointestinal tract, we crossed mice having augmented intestinal epithelial expression of ME1 (ME1-Tg mice) with Apc mice to obtain male Apc /ME1-Tg...