PD-L1, TIM-3, and CTLA-4 blockade fail to promote resistance to secondary infection with virulent strains of Toxoplasma gondii

• Published in: Infection and immunity
• Main Authors: Splitt, Samantha D, Souza, Scott P, Valentine, Kristen M, Castellanos, Brayan E, Curd, Andrew B, Hoyer, Katrina K, Jensen, Kirk D C
• Format: Journal Article
• Language: English
• Published: United States 02.07.2018

T cell exhaustion is a state of hyporesponsiveness that develops during many chronic infections and cancer. Neutralization of inhibitory receptors, or 'checkpoint blockade', can reverse T cell exhaustion and lead to beneficial prognoses in experimental and clinical settings. Whether checkp...