NO from smooth muscle cells decreases NOS expression in endothelial cells: role of TNF-α

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 277; no. 4; p. H1317
• Main Authors: de Frutos, Trinidad, de Miguel, Lourdes Sánchez, García-Durán, Margarita, González-Fernández, Fernando, Rodríguez-Feo, Juan A, Montón, Mercedes, Guerra, José, Farré, Jerónimo, Casado, Santos, López-Farré, Antonio
• Format: Journal Article
• Language: English
• Published: United States 01.10.1999
• Subjects: coculture; tumor necrosis factor-α; nitric oxide donors; endothelial dysfunction; interleukin-1β

Despite the evidence that cytokines stimulate nitric oxide (NO) production by inducible nitric oxide synthase (iNOS), several reports recently demonstrated that the hypotensive response related to endothelial nitric oxide synthase (eNOS) activity could be inhibited by the same cytokines. The aim of...