Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of T H 9 cells

• Published in: Nature communications Vol. 8; no. 1; p. 559
• Main Authors: Rivera Vargas, Thaiz, Cai, Zhijian, Shen, Yingying, Dosset, Magalie, Benoit-Lizon, Isis, Martin, Tiffany, Roussey, Aurélie, Flavell, Richard A, Ghiringhelli, François, Apetoh, Lionel
• Format: Journal Article
• Language: English
• Published: England 15.09.2017
• Subjects: Animals; Autophagy - immunology; Autophagy-Related Protein 5; Autophagy-Related Proteins; Cell Differentiation - immunology; Immunotherapy; Interleukin-9 - immunology; Lymphopoiesis - immunology; Mice; Neoplasms - immunology; Neoplasms - therapy; Proto-Oncogene Proteins - metabolism; T-Lymphocyte Subsets - immunology; T-Lymphocytes, Helper-Inducer - immunology; Trans-Activators - metabolism; Ubiquitin-Conjugating Enzymes

Autophagy, a catabolic mechanism that involves degradation of cellular components, is essential for cell homeostasis. Although autophagy favours the lineage stability of regulatory T cells, the contribution of autophagy to the differentiation of effector CD4 T cells remains unclear. Here we show tha...