Assessing alpha-tocopherol levels in patients with keratocystic odontogenic tumor: A cross-sectional study

A keratocystic odontogenic tumour (KCOT) is a benign uni- or multicystic, intraosseous tumour of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium and potential for aggressive, infiltrative behaviour. Various studies in hamsters showed that, alpha-Toc...

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Published inIndian journal of dental research : official publication of Indian Society for Dental Research Vol. 28; no. 2; p. 122
Main Authors Ayinampudi, Bhargavi Krishna, Varikoti, Sushmita Bhargavi, Baghirath, Pacha Venkat, Vinay, B Hari, Gayathri, Ch, Gannepalli, Ashalata
Format Journal Article
LanguageEnglish
Published India 01.03.2017
Subjects
alpha-Tocopherol - blood
Biomarkers, Tumor - blood
Chromatography, Liquid
Cross-Sectional Studies
Female
Humans
Male
Odontogenic Tumors - blood
Odontogenic Tumors - pathology
Pilot Projects
Tandem Mass Spectrometry
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Summary:A keratocystic odontogenic tumour (KCOT) is a benign uni- or multicystic, intraosseous tumour of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium and potential for aggressive, infiltrative behaviour. Various studies in hamsters showed that, alpha-Tocopherol, which is an active biological form of Vitamin E, is a potent antioxidant known to inhibit tumour formation and also regression of established tumours. So, the aim of the present pilot study was to assess the levels of Alpha-Tocopherol(Vitamin E) in Patients with KCOT and compare them with Vitamin E levels in normal healthy individuals. A sample of 20 individuals were taken and Alpha Tocopherol levels in serum were assessed. Independent sample t test was used to analyse the data. Serum Vitamin-E levels were found to be decreased in KCOT cases. Mean Vitamin-E level was found to be decreased (mean + S.D. = 10,549.34 +/- 2494.21 ng/mL) as compared to healthy controls (mean + S.D. = 13,982.42 +/- 2178.02 ng/mL). The reduction in serum vitamin E level was statistically significant (P < 0.05). The reduction in Vitamin E levels in KCOT patients might be suggestive of the possible interrelation between Vitamin E and KCOT invivo. Also, increase in intake of Vitamin E might help in reducing the risk of recurrence in KCOT by reducing the dysregulation of Cyclin D1 and Down-Regulation of mutant p53.
ISSN:1998-3603