Genistein protects against Aβ 25-35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers

• Published in: BMC neuroscience Vol. 18; no. 1; p. 12
• Main Authors: You, Fuling, Li, Qiao, Jin, Guifang, Zheng, Yaojie, Chen, Jingrong, Yang, Hong
• Format: Journal Article
• Language: English
• Published: England 12.01.2017
• Subjects: Amyloid beta-Peptides - toxicity; Animals; Apoptosis - drug effects; Apoptosis - physiology; Bcl-2-Like Protein 11 - metabolism; Carrier Proteins - metabolism; Caspase 3 - metabolism; Cell Survival - drug effects; Cell Survival - physiology; Cytochromes c - metabolism; Drug Evaluation, Preclinical; Genistein - pharmacology; JNK Mitogen-Activated Protein Kinases - metabolism; Mitochondrial Proteins - metabolism; Neurons - drug effects; Neurons - pathology; Neurons - physiology; Neuroprotective Agents - pharmacology; PC12 Cells; Peptide Fragments - toxicity; Polymerase Chain Reaction; Proto-Oncogene Proteins c-bcl-2 - metabolism; Rats; RNA, Messenger - metabolism; Signal Transduction - drug effects; Bcl-2; Alzheimer’s disease; Genistein; JNK; Apoptosis; Aβ25–35

Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer's disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significant protective effect against Aβ induced neurotoxicity and mitochondrial damage in rat p...