Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABA A Receptor γ2 Subunit in the Cerebellum

• Published in: Frontiers in pharmacology Vol. 7; p. 403
• Main Authors: Leppä, Elli, Linden, Anni-Maija, Aller, Maria I, Wulff, Peer, Vekovischeva, Olga, Luscher, Bernhard, Lüddens, Hartmut, Wisden, William, Korpi, Esa R
• Format: Journal Article
• Language: English
• Published: Switzerland 2016
• Subjects: extrasynaptic GABAA receptors; Purkinje cells; neurosteroids; motor performance; cerebellum

Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABA receptors. In recombinant receptors and genetic mouse models their actions depend on the α, β, and δ subunits of the receptor, especially on those that form extrasynaptic GABA recept...