Genome-wide transcriptome analysis of Aspergillus fumigatus exposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakA HOG1 and MpkC dependent

• Published in: Cellular microbiology Vol. 19; no. 4
• Main Authors: Pereira Silva, Lilian, Alves de Castro, Patrícia, Dos Reis, Thaila Fernanda, Paziani, Mario Henrique, Von Zeska Kress, Márcia Regina, Riaño-Pachón, Diego M, Hagiwara, Daisuke, Ries, Laure N A, Brown, Neil Andrew, Goldman, Gustavo H
• Format: Journal Article
• Language: English
• Published: England 01.04.2017
• Subjects: Animals; Aspergillosis - microbiology; Aspergillus fumigatus - enzymology; Aspergillus fumigatus - genetics; Cell Wall; Female; Fungal Proteins - genetics; Fungal Proteins - metabolism; Gene Expression Profiling; Gene Expression Regulation, Fungal; Gene Ontology; Genome, Fungal; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases - genetics; Mitogen-Activated Protein Kinases - metabolism; Osmotic Pressure; Signal Transduction; Stress, Physiological; Transcription Factors - physiology; Transcriptome

Invasive aspergillosis is predominantly caused by Aspergillus fumigatus, and adaptations to stresses experienced within the human host are a prerequisite for the survival and virulence strategies of the pathogen. The central signal transduction pathway operating during hyperosmotic stress is the hig...