Periprocedural platelet inhibition with cangrelor in P2Y 12 -inhibitor naïve patients with acute coronary syndromes - A matched-control pharmacodynamic comparison in real-world patients

• Published in: International journal of cardiology Vol. 223; p. 848
• Main Authors: Droppa, Michal, Spahn, Pascal, Takhgiriev, Khalid, Müller, Karin A L, Alboji, Ahmed, Straub, Andreas, Rath, Dominik, Jeong, Young-Hoon, Gawaz, Meinrad, Geisler, Tobias
• Format: Journal Article
• Language: English
• Published: Netherlands 15.11.2016
• Subjects: Acute Coronary Syndrome - blood; Acute Coronary Syndrome - therapy; Adenosine Monophosphate - administration & dosage; Adenosine Monophosphate - analogs & derivatives; Adenosine Monophosphate - pharmacokinetics; Administration, Intravenous; Aged; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention - methods; Perioperative Care - methods; Platelet Aggregation - drug effects; Platelet Function Tests - methods; Purinergic P2Y Receptor Antagonists - administration & dosage; Purinergic P2Y Receptor Antagonists - pharmacokinetics; Treatment Outcome; Multiple electrode aggregometry; Thromboelastography; Cangrelor; Acute coronary syndrome; Platelet inhibition

Effective inhibition of platelet aggregation during PCI in high risk patients with ACS is of utmost importance. The new intravenous short acting P2Y -receptor inhibitor cangrelor is available for use in PCI-treated patients. We aimed to study platelet inhibition during treatment with cangrelor and t...