Variant Alleles in XRCC1 Arg194Trp and Arg399Gln Polymorphisms Increase Risk of Gastrointestinal Cancer in Sabah, North Borneo

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 17; no. 4; p. 1925
• Main Authors: Halim, Noor Hanis Abu, Chong, Eric Tzyy Jiann, Goh, Lucky Poh Wah, Chuah, Jitt Aun, See, Edwin Un Hean, Chua, Kek Heng, Lee, Ping-Chin
• Format: Journal Article
• Language: English
• Published: Thailand 2016
• Subjects: Adult; Aged; Alleles; Biomarkers, Tumor - genetics; Borneo - epidemiology; Case-Control Studies; DNA-Binding Proteins - genetics; Female; Follow-Up Studies; Gastrointestinal Neoplasms - epidemiology; Gastrointestinal Neoplasms - etiology; Gastrointestinal Neoplasms - pathology; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Neoplasm Staging; Pilot Projects; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide - genetics; Prognosis; Risk Factors; X-ray Repair Cross Complementing Protein 1

The XRCC1 protein facilitates various DNA repair pathways; single-nucleotide polymorphisms (SNPs) in this gene are associated with a risk of gastrointestinal cancer (GIC) with inconsistent results, but no data have been previously reported for the Sabah, North Borneo, population. We accordingly inve...