Anti-cancer properties of a sesquiterpene lactone-bearing fraction from Artemisia khorassanica
Artemisia species are important medicinal plants throughout the world. The present in vitro study, using a sesquiterpene lactone-bearing fraction prepared from Artemisia khorassanica (SLAK), sought to investigate anti-cancer properties of this plant and elucidate potential underlying mechanisms for...
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Published in | Asian Pacific journal of cancer prevention : APJCP Vol. 16; no. 3; p. 863 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Thailand
2015
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Subjects | |
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Abstract | Artemisia species are important medicinal plants throughout the world. The present in vitro study, using a sesquiterpene lactone-bearing fraction prepared from Artemisia khorassanica (SLAK), sought to investigate anti-cancer properties of this plant and elucidate potential underlying mechanisms for the effects.
Anti-cancer potential was evaluated by toxicity against human melanoma and fibroblast cell lines. To explore the involved pathways, pattern of any cell death was determined using annexin-V/PI staining and also the expression of Bax and cytochrome c was investigated by Western blotting.
The results showed that SLAK selectively caused a concentration-related inhibition of proliferation of melanoma cells that was associated with remarkable increase in early events and over-expression of both Bax and cytochrome c.
The current experiment indicates that Artemisia may have anti-cancer activity. We anticipate that the ingredients may be employed as therapeutic candidates for melanoma. |
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AbstractList | Artemisia species are important medicinal plants throughout the world. The present in vitro study, using a sesquiterpene lactone-bearing fraction prepared from Artemisia khorassanica (SLAK), sought to investigate anti-cancer properties of this plant and elucidate potential underlying mechanisms for the effects.
Anti-cancer potential was evaluated by toxicity against human melanoma and fibroblast cell lines. To explore the involved pathways, pattern of any cell death was determined using annexin-V/PI staining and also the expression of Bax and cytochrome c was investigated by Western blotting.
The results showed that SLAK selectively caused a concentration-related inhibition of proliferation of melanoma cells that was associated with remarkable increase in early events and over-expression of both Bax and cytochrome c.
The current experiment indicates that Artemisia may have anti-cancer activity. We anticipate that the ingredients may be employed as therapeutic candidates for melanoma. |
Author | Emami, Seyed Ahmad Tabasi, Nafise Rastin, Maryam Mahmoudi, Mahmoud Iranshahi, Mehrdad Rabe, Shahrzad Taghizadeh |
Author_xml | – sequence: 1 givenname: Shahrzad Taghizadeh surname: Rabe fullname: Rabe, Shahrzad Taghizadeh email: mahmoudim@mums.ac.ir organization: Immunology Research Center, Bu-Ali Research Institute, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran E-mail : mahmoudim@mums.ac.ir – sequence: 2 givenname: Seyed Ahmad surname: Emami fullname: Emami, Seyed Ahmad – sequence: 3 givenname: Mehrdad surname: Iranshahi fullname: Iranshahi, Mehrdad – sequence: 4 givenname: Maryam surname: Rastin fullname: Rastin, Maryam – sequence: 5 givenname: Nafise surname: Tabasi fullname: Tabasi, Nafise – sequence: 6 givenname: Mahmoud surname: Mahmoudi fullname: Mahmoudi, Mahmoud |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25735374$$D View this record in MEDLINE/PubMed |
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Snippet | Artemisia species are important medicinal plants throughout the world. The present in vitro study, using a sesquiterpene lactone-bearing fraction prepared from... |
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SubjectTerms | Apoptosis - drug effects Artemisia - chemistry Blotting, Western Caspases - metabolism Cell Cycle - drug effects Cell Proliferation - drug effects Cells, Cultured Cytochromes c - metabolism Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Humans Lactones - pharmacology Melanoma - drug therapy Melanoma - metabolism Melanoma - pathology Plant Components, Aerial - chemistry Plant Extracts - pharmacology Sesquiterpenes - pharmacology |
Title | Anti-cancer properties of a sesquiterpene lactone-bearing fraction from Artemisia khorassanica |
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