56 Fe Particle Exposure Results in a Long-Lasting Increase in a Cellular Index of Genomic Instability and Transiently Suppresses Adult Hippocampal Neurogenesis in Vivo

• Published in: Life sciences in space research Vol. 2; p. 70
• Main Authors: DeCarolis, Nathan A, Rivera, Phillip D, Ahn, Francisca, Amaral, Wellington Z, LeBlanc, Junie A, Malhotra, Shveta, Shih, Hung-Ying, Petrik, David, Melvin, Neal, Chen, Benjamin P C, Eisch, Amelia J
• Format: Journal Article
• Language: English
• Published: Netherlands 01.07.2014
• Subjects: adult neurogenesis; transgenic mice; subgranular zone; recovery; galactic cosmic radiation; BrdU

The high-LET HZE particles from galactic cosmic radiation pose tremendous health risks to astronauts, as they may incur sub-threshold brain injury or maladaptations that may lead to cognitive impairment. The health effects of HZE particles are difficult to predict and unfeasible to prevent. This und...