Effectiveness of haemodiafiltration with ultrafiltrate regeneration in the reduction of light chains in multiple myeloma with renal failure

• Published in: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia Vol. 33; no. 6; p. 788
• Main Authors: Pendón-Ruiz de Mier, María Victoria, Alvarez-Lara, María Antonia, Ojeda-López, Raquel, Martín-Malo, Alejandro, Carracedo, Julia, Caballero-Villarraso, Javier, Alonso, Corona, Aljama, Pedro
• Format: Journal Article
• Language: English
• Published: Spain 13.11.2013
• Subjects: Acute Kidney Injury - blood; Acute Kidney Injury - therapy; Adsorption; Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Boronic Acids - administration & dosage; Bortezomib; Combined Modality Therapy; Cyclophosphamide - administration & dosage; Dexamethasone - administration & dosage; Female; Hemodiafiltration - methods; Humans; Immunoglobulin kappa-Chains - blood; Immunoglobulin lambda-Chains - blood; Ion Exchange Resins; Male; Membranes, Artificial; Middle Aged; Multiple Myeloma - blood; Multiple Myeloma - complications; Multiple Myeloma - drug therapy; Myeloma Proteins - analysis; Polymers; Pyrazines - administration & dosage; Serum Albumin - analysis; Thalidomide - administration & dosage; Treatment Outcome

Acute kidney failure in multiple myeloma (MM) occurs in 12%-20% of patients and is a poor prognostic factor for patient survival. Recent studies have shown that dialysis with a High-Cut-Off membrane (HCO) removes free light chains (FLC) effectively although with significant albumin loss. Other adsor...