The role of T-lymphocytes in the development of a humoral immune response to the corpuscular antigen of Staphylococcus aureus

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 1; p. 72
• Main Authors: Liashchenko, K P, Bobrovnik, S A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.01.1990
• Subjects: Animals; Antibody Formation - immunology; Antibody-Producing Cells - immunology; Antigen-Antibody Reactions - immunology; Antigens, Bacterial - immunology; Immunologic Memory - immunology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Nude; Staphylococcus aureus - immunology; T-Lymphocytes - immunology
• ISSN: 0372-9311

The dependence of humoral immune response and the formation of immunological memory to corpuscular staphylococcal antigen (CSA) on the T-system of immunity was studied in experiments on B-mice and on mice with the congenital absence of the thymus (nude). Primary and secondary immune response to CSA in athymic mice was found to be considerably less than in normal animals. After the repeated immunization of genetically athymic mice the pronounced secondary reaction of the formation of antibodies to CSA was observed. As shown in this investigation carried out with the use of adoptive transfer techniques, the induction of memory B-cells to CSA may occur in animals with congenital or experimentally induced T-immunodeficiency. The conclusion was made on the T-dependence of humoral immune response to CSA, the formation of immunological memory to this antigen being relatively T-independent.