Increased production of nitric oxide mediates selective organ-specific effects of endotoxin on oxidative stress

• Published in: Anti-inflammatory & anti-allergy agents in medicinal chemistry Vol. 11; no. 2; p. 161
• Main Authors: Sahan-Firat, Seyhan, Canacankatan, Necmiye, Korkmaz, Belma, Yildirim, Hatice, Tamer, Lulufer, Buharalioglu, C Kemal, Sari, A Nihal, Kacan, Meltem, Unsal, Demet, Tunctan, Bahar
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 2012
• Subjects: Animals; Endotoxins - toxicity; Glutathione - metabolism; Male; Malondialdehyde - analysis; Nitric Oxide - biosynthesis; Nitric Oxide Synthase Type II - antagonists & inhibitors; Organ Specificity; Oxidative Stress - drug effects; Rats; Rats, Wistar

Endotoxemic shock is a systemic inflammatory response that is associated with increased nitric oxide (NO) production by inducible NO synthase (iNOS) which contributes to hypotension, vascular hyporeactivity, and multiple organ failure. Oxidative stress (OS) is a major contributing factor to high mor...