Evaluation of the relative efficacy of an alloplast used alone and in conjunction with an osteoclast inhibitor in the treatment of human periodontal infrabony defects: a clinical and radiological study

• Published in: Indian journal of dental research : official publication of Indian Society for Dental Research Vol. 22; no. 2; p. 225
• Main Authors: Gupta, Jyoti, Gill, Amarjit Singh, Sikri, Poonam
• Format: Journal Article
• Language: English
• Published: India 01.03.2011
• Subjects: Adult; Alendronate - therapeutic use; Alveolar Bone Loss - diagnostic imaging; Alveolar Bone Loss - surgery; Alveolar Process - diagnostic imaging; Alveolar Process - pathology; Bone Density Conservation Agents - therapeutic use; Bone Substitutes - therapeutic use; Chronic Periodontitis - pathology; Chronic Periodontitis - surgery; Durapatite - therapeutic use; Female; Follow-Up Studies; Guided Tissue Regeneration, Periodontal - methods; Humans; Male; Middle Aged; Osteoclasts - drug effects; Periodontal Attachment Loss - pathology; Periodontal Attachment Loss - surgery; Periodontal Pocket - pathology; Periodontal Pocket - surgery; Radiography; Single-Blind Method; Treatment Outcome

Mucoperiosteal flap surgery stimulates varying amounts of alveolar bone loss due to accelerated osteoclastic activity [Regional Accelerated Phenomenon (RAP)]. Alendronate sodium inhibits osteoclastic activity and is thought to result in a net increase in osteoblastic activity. We undertook a prelimi...