The effect of ozonated physiological solution on the postreperfused lipid composition and the level of carbohydrate metabolism substrates

The effect of ozonated physiological solution on lipid composition, lipid peroxidation and level of carbohydrate metabolism substrates were investigated in the early reperfusion period. The total ischemia/reperfusion model was used. This study shows that injection of ozonated physiological solution...

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Bibliographic Details
Published inBiomeditsinskaia khimiia Vol. 55; no. 6; p. 750
Main Authors Andreeva, N N, Solov'eva, T I, Balandina, M V, Mukhina, I V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.2009
Subjects
Animals
Carbohydrate Metabolism - drug effects
Lipid Metabolism - drug effects
Lipid Peroxidation - drug effects
Male
Myocardium - metabolism
Myocytes, Cardiac - metabolism
Oxidants, Photochemical - pharmacology
Ozone - pharmacology
Perfusion
Rats
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Summary:The effect of ozonated physiological solution on lipid composition, lipid peroxidation and level of carbohydrate metabolism substrates were investigated in the early reperfusion period. The total ischemia/reperfusion model was used. This study shows that injection of ozonated physiological solution in the early reperfusion period did not prevent cardiac myocyte membrane delipidization, activation of lipid peroxidation due to antioxidation exhaustion. Treatment with ozonated physiological solution promotes normalization in the lysophosphatidylholine and lysophosphatidylserine content, activation of hydrolytic degradation of neutral lipids, the decrease in membrane lipid microviscosity, activation of the aerobic glucose utilization and prevents lactic acidosis in the heart.
ISSN:2310-6972