The time course of changes in cell immunological parameters during administration of live dry plague vaccine

The study of the time course of changes in cell immunological parameters by a magnetic separation technique in human beings during the administration of plague vaccine in relation to the immunological load revealed the higher blood levels of all T lymphocyte subpopulations on day 14 after vaccinatio...

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Published inKlinicheskaia laboratornaia diagnostika no. 8; p. 24
Main Authors Bogacheva, N V, Darmov, I V, Borisevich, I V, Kriuchkov, A V, Pechenkin, D V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.08.2009
Subjects
Anthrax Vaccines - immunology
B-Lymphocytes - immunology
Bacterial Vaccines - immunology
Francisella tularensis - immunology
Humans
Immunity, Cellular
Plague - immunology
Plague - prevention & control
Plague Vaccine - immunology
T-Lymphocyte Subsets - immunology
T-Lymphocytes - immunology
Vaccination
Vaccines, Attenuated - immunology
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Summary:The study of the time course of changes in cell immunological parameters by a magnetic separation technique in human beings during the administration of plague vaccine in relation to the immunological load revealed the higher blood levels of all T lymphocyte subpopulations on day 14 after vaccination. These changes are most typical of a primary vaccinated cohort. The increased frequency of plague vaccine administration and multiple immunizations with live plague, anthrax, and tularemia vaccines produce the time-course of changes in T lymphocyte populations (subpopulations) in response to the regular administration of plague vaccine. A high immunological load in man also promotes a significant reduction in the level of B lymphocytes.
ISSN:0869-2084