Serological markers of viral infections and various indicators of immunity in patients with hemophilia

The authors have studied the incidence rate for markers of viruses of AIDS (HIV), hepatitis B (HBV) and cytomegalia (CMV), as well as certain parameters of antiinfectious defense in hemophilia patients. A high incidence rate of HBV and CMV markers was established in the investigated patients, and am...

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Published inGematologiia i transfuziologiia Vol. 35; no. 10; p. 21
Main Authors Golosova, T V, Somova, A V, Margolina, A N, Tupoleva, T A, Vavilova, L M, Kuz'micheva, M Iu, Likhacheva, E A, Pliushch, O P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.10.1990
Subjects
Acquired Immunodeficiency Syndrome - complications
Acquired Immunodeficiency Syndrome - immunology
Antibodies, Viral - analysis
Biomarkers - blood
Complement System Proteins - analysis
Cytomegalovirus - immunology
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - immunology
Hemophilia A - complications
Hemophilia A - immunology
Hepatitis B - complications
Hepatitis B - immunology
Hepatitis B virus - immunology
HIV-1 - immunology
Humans
Immunoglobulins - analysis
Male
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Summary:The authors have studied the incidence rate for markers of viruses of AIDS (HIV), hepatitis B (HBV) and cytomegalia (CMV), as well as certain parameters of antiinfectious defense in hemophilia patients. A high incidence rate of HBV and CMV markers was established in the investigated patients, and among them no seropositive subjects, by antibodies to HIV, were detected. In the presence of a low incidence rate of chronic HBsAg-carriership in this category of patients, a significant number of immune subjects was observed, that correlated with a relative stability of such immunity parameters as concentration of serum immunoglobulin G and the level of circulating immune complexes.
ISSN:0234-5730