Effects of inhibitors of Delta24(25)-sterol methyl transferase on the ultrastructure of epimastigotes of Trypanosoma cruzi

• Published in: Microscopy and microanalysis Vol. 11; no. 6; p. 506
• Main Authors: Braga, Marina V, Magaraci, Filippo, Lorente, Silvia Orenes, Gilbert, Ian, de Souza, Wanderley
• Format: Journal Article
• Language: English
• Published: United States 01.12.2005
• Subjects: Animals; Autophagy; Cell Membrane - drug effects; Cell Membrane - ultrastructure; Enzyme Inhibitors - pharmacology; Methyltransferases - antagonists & inhibitors; Trypanocidal Agents - pharmacology; Trypanosoma cruzi - drug effects; Trypanosoma cruzi - growth & development; Trypanosoma cruzi - ultrastructure; Vacuoles - drug effects; Vacuoles - ultrastructure

Trypanosoma cruzi is the ethiological agent of Chagas disease. New compounds are being developed based on the biosynthesis and function of sterols, because T. cruzi has a requirement for specific endogenous sterols for growth and survival. Sterol biosynthesis inhibitors (SBIs) are drugs commonly use...