Endometrial evaluation in menopausal women after six months of isoflavones

• Published in: Revista da Associação Médica Brasileira (1992) Vol. 52; no. 6; p. 419
• Main Authors: Wolff, Luis Paulo Galvão, Martins, Marcos Roberto, Bedone, Aloísio José, Monteiro, Ilza Maria Urbano
• Format: Magazine Article
• Language: Portuguese
• Published: Brazil 01.11.2006
• Subjects: Adult; Biopsy; Endometrial Hyperplasia - etiology; Endometrium - drug effects; Endometrium - pathology; Female; Hot Flashes; Humans; Hyperplasia; Hysteroscopy; Isoflavones - adverse effects; Menopause; Middle Aged; Prospective Studies; Time Factors; Uterine Diseases - diagnosis; Uterine Diseases - etiology; Uterine Hemorrhage - etiology
• ISSN: 0104-4230

To evaluate the endometrium of menopausal women before and after six months use of total isoflavone. A non-controlled clinical, type "before and after" trial was carried out with 32 post-menopause women, between 40 and 60 years of age. They received 80 mg/day of total isoflavones obtained from Trifolium pratense (Climadilâ) during six months. They were evaluated at the beginning and end of treatment by transvaginal pelvic ecography, hysteroscopy and endometrial biopsy. Data collected were registered by means of the Epi info, version 6.04 b software, data analysis was made using the SAS version 8.2 statistics program, considering a significance level (alpha) of 0.05 and a 0.80 power (1-beta). In order to study the average variation of endometrial thickness and variation of the hysteroscopic and hystologic findings the t Student test for paired data was used. Among the 32 participant women, six presented vaginal bleeding and three presented endometrial alteration when compared to the initial exams. Two of the women developed endometrial cell proliferation and one of them endometrial hyperplasia. There were no significant alterations in relation to endometrial thickness. In this study, three women who used isoflavones during the six month period presented endometrial activity.