The effect of valsartan, an angiotensin II receptor antagonist, on portal and systemic hemodynamics and on renal function in liver cirrhosis

• Published in: Journal of gastrointestinal and liver diseases : JGLD Vol. 15; no. 4; p. 337
• Main Authors: Fierbinteanu-Braticevici, Carmen, Dragomir, Paul, Tribus, Laura, Negreanu, Lucian, Bengus, Andreea, Usvat, Radu, Andronescu, Dan
• Format: Journal Article
• Language: English
• Published: Romania 01.12.2006
• Subjects: Adult; Aged; Aldosterone - blood; Angiotensin II Type 1 Receptor Blockers - therapeutic use; Antihypertensive Agents - therapeutic use; Biomarkers - blood; Biomarkers - urine; Creatinine - blood; Female; Hemodynamics - drug effects; Humans; Hypertension, Portal - drug therapy; Hypertension, Portal - etiology; Hypertension, Portal - metabolism; Hypertension, Portal - physiopathology; Kidney - drug effects; Kidney - physiopathology; Liver Cirrhosis - complications; Liver Cirrhosis - drug therapy; Liver Cirrhosis - metabolism; Liver Cirrhosis - physiopathology; Male; Metanephrine - urine; Middle Aged; Natriuresis - drug effects; Portal System - drug effects; Portal System - physiopathology; Renin - blood; Romania; Single-Blind Method; Sodium - urine; Tetrazoles - therapeutic use; Time Factors; Treatment Outcome; Valine - analogs & derivatives; Valine - therapeutic use; Valsartan; Romania

The aim of the study was to assess the effects of valsartan, a new generation angiotensin II receptor antagonist, on portal and systemic hemodynamics and on renal function in cirrhosis. Eighty patients with cirrhosis and portal hypertension were divided in two groups as follows: group I - 40 patient...