Syphilis as a chronic systemic infection

During the last STDs'epidemic in Russia (1994 - 2004) over 2.7 min people have been infected with syphilis. At present the structure of syphilis morbidity is characterized by 37% of latent forms, including 1.5% late latency. The increased level of late latency may result from: an ever-growing n...

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Bibliographic Details
Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 4; p. 120
Main Authors Nesterenko, V G, Akovbian, V A, Semenova, E N, Vavilova, L M, Iudina, T I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2006
Subjects
Anti-Bacterial Agents - administration & dosage
Antigens, Bacterial - immunology
Carrier State
Chronic Disease
Disease Outbreaks
Hepatitis B - complications
Hepatitis C - complications
Herpes Simplex - complications
Humans
Immunity, Cellular
Macrophages - microbiology
Phagocytosis
Risk Factors
Russia - epidemiology
Syphilis - complications
Syphilis - epidemiology
Syphilis - immunology
Syphilis - microbiology
Treponema pallidum - immunology
Treponema pallidum - pathogenicity
Virulence
Russia
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Summary:During the last STDs'epidemic in Russia (1994 - 2004) over 2.7 min people have been infected with syphilis. At present the structure of syphilis morbidity is characterized by 37% of latent forms, including 1.5% late latency. The increased level of late latency may result from: an ever-growing number of those with asymptomatic syphilis; disorderly and self-dependent usage of antibacterial preparations; spread of the virus chronic infections (herpes, hepatitis B, C) altering the macroorganism immune response; alcohol and drug abuse which decreases the efficacy of specific therapy. In general, chronization of the syphilitic infection may be caused by antigenically inert treponemal cell surface; paucity of outer membrane protein; residence of treponemas within an immunoprotective niche; uncompleted phagocytosis of treponemes with macrophages. Syphilis remains an "infectio magna" and demands thorough attention to all diagnostic and therapeutic procedures on every stage of the disease.
ISSN:0372-9311
2686-7613