Locomotor activity and expression of c-Fos protein in the brain of C57BL and Balb/c mice: effects of D-amphetamine and sydnocarb

Effects of the psychostimulants D-amphetamine and sydnocarb on the locomotor activity and c-Fos protein expression in the brain of C57BL and BALB/c mice was studied. The drugs significantly increase the locomotor activity and the level of c-Fos protein in the brain structures of both lines. The effe...

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Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 65; no. 5; p. 18
Main Authors Novoselov, I A, Cherepov, A B, Raevskiĭ, K S, Anokhin, K V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.2002
Subjects
Animals
Brain - metabolism
Central Nervous System Stimulants - pharmacology
Dextroamphetamine - pharmacology
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Motor Activity - drug effects
Proto-Oncogene Proteins c-fos - biosynthesis
Sydnones - pharmacology
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Summary:Effects of the psychostimulants D-amphetamine and sydnocarb on the locomotor activity and c-Fos protein expression in the brain of C57BL and BALB/c mice was studied. The drugs significantly increase the locomotor activity and the level of c-Fos protein in the brain structures of both lines. The effect of D-amphetamine with respect to the locomotor activity was more pronounced in C57BL mice, which correlates with a higher level of the c-Fos expression in the secondary motor cortex. At the same time syndocarb more significantly than D-amphetamine induces expression of the c-Fos protein in the nucleus accumbens core of C57BL mice. Injection of an 0.85% NaCl solution led to a moderate increase in the locomotor activity in the mice of both lines, while the c-Fos expression in the secondary motor cortex and septum was more pronounced in C57BL than in BALB/c mice.
ISSN:0869-2092