Mining the quantitative trait loci associated with oral glucose tolerance in the OLETF rat

• Published in: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing p. 367
• Main Authors: Nakaya, A, Hishigaki, H, Morishita, S
• Format: Journal Article
• Language: English
• Published: United States 2000
• Subjects: Animals; Computer Simulation; Diabetes Mellitus, Type 2 - genetics; Female; Genetic Markers; Glucose Tolerance Test; Linear Models; Lod Score; Male; Models, Genetic; Quantitative Trait, Heritable; Rats; Rats, Inbred F344; Rats, Mutant Strains

Although the synergetic effects of multiple marker loci regarding quantitative traits such as blood glucose level have attracted interest, previous conclusions have been based on assumptions that each marker locus behaves independently of the other, leading to approximation. To cope with this proble...