The Atlantic salmon Z-DNA binding protein kinase phosphorylates translation initiation factor 2 alpha and constitutes a unique orthologue to the mammalian dsRNA-activated protein kinaseR

• Published in: The FEBS journal Vol. 275; no. 1; pp. 184 - 197
• Main Authors: Bergan, Veronica, Jagus, Rosemary, Lauksund, Silje, Kileng, Oeyvind, Robertsen, Boerre
• Format: Journal Article
• Language: English
• Published: 01.01.2008
• Subjects: Escherichia coli; Marine; Oncorhynchus tshawytscha; Salmo salar

The translation initiation factor 2 alpha (eIF2 alpha )-kinase, dsRNA-activated protein kinase (PKR), constitutes one of the major antiviral proteins activated by viral infection of vertebrates. PKR is activated by viral double-stranded RNA and subsequently phosphorylates the alpha -subunit of trans...