Enhancement of aqueous solubility of tricyclic acyclovir derivatives by their complexation with hydroxypropyl- Delta b-cyclodextrin

• Published in: Journal of thermal analysis and calorimetry Vol. 101; no. 2; pp. 555 - 560
• Main Authors: Zielenkiewicz, Wojciech, Kozbial, Malgorzata, Golankiewicz, Bozenna, Poznanski, Jaroslaw
• Format: Journal Article
• Language: English
• Published: 01.08.2010
• Subjects: Aqueous solutions; Buffers; Calorimetry; Complexation; Derivatives; Differential scanning calorimetry; Extinction; Solubility

Solubilities of tricyclic acyclovir derivatives in buffered aqueous solutions of hydroxypropyl- Delta *b-cyclodextrin (HP- Delta *b-CD) at pH 5.5 and 7.0 were determined at 25 and 37 ?C. Complexation of these compounds with HP- Delta *b-CD resulted in a noticeable increase of their solubility; never...