Bilirubin Attenuates Bufadienolide-Induced Ventricular Arrhythmias and Cardiac Dysfunction in Guinea-Pigs by Reducing Elevated Intracellular Na super(+) Levels

• Published in: Cardiovascular toxicology Vol. 12; no. 1; pp. 83 - 89
• Main Authors: Ma, Hongyue, Zhang, Junfeng, Jiang, Jiejun, Zhou, Jing, Xu, Huiqin, Zhan, Zhen, Wu, Qinan, Duan, Jinao
• Format: Journal Article
• Language: English
• Published: 01.03.2012
• Subjects: Amphibia; Antioxidants; Antitumor agents; Arrhythmia; Bilirubin; Blood pressure; Cardiac muscle; Development; Fibrillation; Gastric cancer; Heart; Heart diseases; Na super(+)/K super(+)-exchanging ATPase; Nerve conduction; Sodium; Tachycardia; Venom; Ventricle

Bufadienolides, known ligands of the sodium pump, have been shown to inhibit the proliferation of several cancer cell types. However, their development to date as anticancer agents has been impaired by a narrow therapeutic margin resulting from their potential to induce cardiotoxicity. In the presen...