Experimental radioimmunotherapy with super(186)Re-MAG3-A7 anti-colorectal cancer monoclonal antibody: Comparison with super(131)I-counterpart
A murine IgG1 against aMr 45 kD tumor-associated glycoprotein in human colorectal cancer, A7, was radiolabeled with super(186)Re by a chelating method with a mercaptoacetyltriglycine (MAG3). Its specific activity was 119 MBq/mg, which would be high enough for a therapeutic purpose, and its immunorea...
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| Published in | Annals of nuclear medicine Vol. 15; no. 3; pp. 199 - 202 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.06.2001
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| Online Access | Get full text |
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| Abstract | A murine IgG1 against aMr 45 kD tumor-associated glycoprotein in human colorectal cancer, A7, was radiolabeled with super(186)Re by a chelating method with a mercaptoacetyltriglycine (MAG3). Its specific activity was 119 MBq/mg, which would be high enough for a therapeutic purpose, and its immunoreactivity was preserved well as was super(131)I-A7 labeled by the chloramine-T method. Growth of human colon cancer xenografts, 9.14c0.44 mm in diameter, in nude mice was significantly suppressed by an intravenous dose of 4.48 MBq of super(186)Re-A7. The therapeutic outcome with super(186)Re-A7 was better than that with 4.63 MBq of super(131)I-A7. Toxicity of treatments assessed by body weight change was similar with both conjugates. These results are likely caused by the tumor size and more favorable physical properties of super(186)Re than those of super(131)I. |
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| AbstractList | A murine IgG1 against aMr 45 kD tumor-associated glycoprotein in human colorectal cancer, A7, was radiolabeled with super(186)Re by a chelating method with a mercaptoacetyltriglycine (MAG3). Its specific activity was 119 MBq/mg, which would be high enough for a therapeutic purpose, and its immunoreactivity was preserved well as was super(131)I-A7 labeled by the chloramine-T method. Growth of human colon cancer xenografts, 9.14c0.44 mm in diameter, in nude mice was significantly suppressed by an intravenous dose of 4.48 MBq of super(186)Re-A7. The therapeutic outcome with super(186)Re-A7 was better than that with 4.63 MBq of super(131)I-A7. Toxicity of treatments assessed by body weight change was similar with both conjugates. These results are likely caused by the tumor size and more favorable physical properties of super(186)Re than those of super(131)I. |
| Author | Kinuya, Seigo Kobayashi, Katsutoshi Michigishi, Takatoshi Tonami, Norihisa Onoma, Katsuyuki Watanabe, Naoto Yokoyama, Kunihiko Bunko, Hisashi Motoishi, Shoji Shuke, Noriyuki |
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| Title | Experimental radioimmunotherapy with super(186)Re-MAG3-A7 anti-colorectal cancer monoclonal antibody: Comparison with super(131)I-counterpart |
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