Regulation of I-asynuclein expression in cultured cortical neurons

• Published in: Journal of neurochemistry Vol. 117; no. 2; pp. 275 - 285
• Main Authors: Clough, Richard Lee, Dermentzaki, Georgia, Haritou, Maria, Petsakou, Afroditi, Stefanis, Leonidas
• Format: Journal Article
• Language: English
• Published: 01.04.2011
• Subjects: Animal models; Antibodies; Attention; Brain-derived neurotrophic factor; Cell culture; Cortex; Differentiation; Exons; Introns; Neurons; Neurotransmitter release; Neurotrophic factors; Neurotrophins; Pheochromocytoma cells; Promoters; Protein-tyrosine kinase receptors; Regulatory sequences; Signal transduction; Transcription; Transcription activation; Transfection

Alpha-synuclein (SNCA) is a predominantly neuronal protein involved in the control of neurotransmitter release. The levels of SNCA expression are closely linked to the pathogenesis of Parkinson's disease; however, the biochemical pathways and transcriptional elements that control SNCA expressio...