New epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjoegren's syndrome

• Published in: Clinical and experimental immunology Vol. 162; no. 1; pp. 53 - 61
• Main Authors: Tsuboi, H, Matsumoto, I, Wakamatsu, E, Nakamura, Y, Iizuka, M, Hayashi, T, Goto, D, Ito, S, Sumida, T
• Format: Journal Article
• Language: English
• Published: 01.10.2010

SummaryM3 muscarinic acetylcholine receptor (M3R) plays a crucial role in the secretion of saliva from salivary glands. It is reported that some patients with Sjoegren's syndrome (SS) carried inhibitory autoantibodies against M3R. The purpose of this study is to clarify the epitopes and functio...