Malignant T Cells Exhibit CD45 Resistant Stat3 Activation and Proliferation in Cutaneous T-Cell Lymphoma

• Published in: The Open leukemia journal Vol. 3; pp. 9 - 15
• Main Authors: Krejsgaard, Thorbjorn, Helvad, Rikke, Ralfkiaer, Elisabeth, Astvad, Karen, Gronbaek, Kirsten, Eriksen, Karsten W, Geisler, Carsten, Kopp, Katharina, Zhang, Qian, Odum, Niels, Woetmann, Anders
• Format: Journal Article
• Language: English
• Published: 01.01.2010

CD45 is a protein tyrosine phosphatase, which is well-known for regulating antigen receptor signalling in T and B cells via its effect on Src kinases. It has recently been shown that CD45 can also dephosphorylate Janus kinases (Jaks) and thereby regulate Signal transducer and activator of transcript...