BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies

• Published in: The Lancet (British edition) Vol. 20; pp. 1393 - 1401
• Main Authors: Black, G F, Weir, R E, Floyd, S, Bliss, L, Warndorff, D K, Crampin, A C, Ngwira, B, Sichali, L, Nazareth, B, Blackwell, J M, Branson, K, Chaguluka, S D, Donovan, L, Jarman, E, King, E, Fine, P E M, Dockrell, H M
• Format: Journal Article
• Language: English
• Published: 01.04.2002
• Subjects: Efficacy; Immune response; Malawi; Randomized controlled trials; Tuberculosis; Vaccines

The efficacy of BCG vaccines against pulmonary tuberculosis varies between populations, showing no protection in Malawi but 50-80% protection in the UK. To investigate the mechanism underlying these differences, randomised controlled studies were set up to measure vaccine-induced immune responsivene...