Quantitation of cannabinoid CB(1) receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand

• Published in: NeuroImage (Orlando, Fla.) Vol. 48; no. 2; pp. 362 - 370
• Main Authors: Terry, Garth E, Liow, Jeih-San, Zoghbi, Sami S, Hirvonen, Jussi, Farris, Amanda G, Lerner, Alicja, Tauscher, Johannes T, Schaus, John M, Phebus, Lee, Felder, Christian C, Morse, Cheryl L, Hong, Jinsoo S, Pike, Victor W, Halldin, Christer, Innis, Robert B
• Format: Journal Article
• Language: English
• Published: 01.11.2009

[(11)C]MePPEP is a high affinity, CB(1) receptor-selective, inverse agonist that has been studied in rodents and monkeys. We examined the ability of [(11)C]MePPEP to quantify CB(1) receptors in human brain as distribution volume calculated with the "gold standard" method of compartmental m...