Posterior urethral valves: Clinical audits of presentation, diagnostic and therapeutic intervention in a nigerian teaching hospital

• Published in: International urology and nephrology
• Main Authors: Ojewuyi, Olufemi O, Ayeni, Temitope O, Ojewuyi, Abiodun R, Bamikefa, Titilope A, Aderibigbe, Gbenga A, Oyeniyi, Adebukola G, Eziyi, Amogu K
• Format: Journal Article
• Language: English
• Published: 04.10.2024
• DOI: 10.1007/s11255-024-04221-3
• ISSN: 1573-2584

We described our experience in the management of PUV at UNIOSUN Teaching Hospital, Osogbo, Osun State.PURPOSEWe described our experience in the management of PUV at UNIOSUN Teaching Hospital, Osogbo, Osun State.This was a retrospective analysis of patients with diagnosis of PUV carried out over a 4 year period (2019-2023). Demographic characteristics, clinical presentation, diagnosis and mode of therapeutic interventions were the variables analysed.METHODSThis was a retrospective analysis of patients with diagnosis of PUV carried out over a 4 year period (2019-2023). Demographic characteristics, clinical presentation, diagnosis and mode of therapeutic interventions were the variables analysed.A total of 17 patients with PUV were managed during the study period. Median age at presentation and surgery were 10 months (range 3.0-48.0) and 13 months (range 3.0-49.5), respectively. Most common presentation was poor urinary stream, 11 (64.7%). Mean PCV was 34.42%. Klebsiella aerogens was the predominant 9 (52.9%) organism isolated. A patient had prenatal USS diagnosis suggestive of PUV, majority (52.9%) had bilateral grade 1 V hydronephrosis at presentation. Voiding cystogram was diagnostic in 14 patients, (82.4%) while urethrocystoscopy was done in 14 (82.4%) patients. Median creatinine level were 116, 76.5 and 51.0 (micromol/l) pre- and post-catheterization and 1 month post-surgery, respectively. There was positive correlation between the age and post- surgery creatinine but a negative correlation between the PCV and grade of hydronephrosis. All patients had Mohans valvotomy. We had mortality in a patient from urosepsis. At 6 months-1 year follow-up, 15 patients had good urine stream with stable renal function.RESULTSA total of 17 patients with PUV were managed during the study period. Median age at presentation and surgery were 10 months (range 3.0-48.0) and 13 months (range 3.0-49.5), respectively. Most common presentation was poor urinary stream, 11 (64.7%). Mean PCV was 34.42%. Klebsiella aerogens was the predominant 9 (52.9%) organism isolated. A patient had prenatal USS diagnosis suggestive of PUV, majority (52.9%) had bilateral grade 1 V hydronephrosis at presentation. Voiding cystogram was diagnostic in 14 patients, (82.4%) while urethrocystoscopy was done in 14 (82.4%) patients. Median creatinine level were 116, 76.5 and 51.0 (micromol/l) pre- and post-catheterization and 1 month post-surgery, respectively. There was positive correlation between the age and post- surgery creatinine but a negative correlation between the PCV and grade of hydronephrosis. All patients had Mohans valvotomy. We had mortality in a patient from urosepsis. At 6 months-1 year follow-up, 15 patients had good urine stream with stable renal function.Early intervention assist in optimizing renal and bladder function and minimize risk of urosepsis. Where there is no facility for endoscopic valve ablation, Mohans valvotomy remains a viable treatment option.CONCLUSIONEarly intervention assist in optimizing renal and bladder function and minimize risk of urosepsis. Where there is no facility for endoscopic valve ablation, Mohans valvotomy remains a viable treatment option.