Total Synthesis of the Phenylnaphthacenoid Type II Polyketide Antibiotic Formicamycin H via Regioselective Ruthenium-Catalyzed Hydrogen Auto-Transfer 4 + 2 Cycloaddition

The first total synthesis of the pentacyclic phenylnaphthacenoid type II polyketide antibiotic formicamycin H is described. A key feature of the synthesis involves the convergent, regioselective assembly of the tetracyclic core via ruthenium-catalyzed α-ketol-benzocyclobutenone [4 + 2] cycloaddition...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 146; no. 38; p. 26351
Main Authors Hu, Guanyu, Doerksen, Rosalie S, Ambler, Brett R, Krische, Michael J
Format Journal Article
LanguageEnglish
Published 25.09.2024
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