Stereoselective Asymmetric Syntheses of Molecules with a 4,5-Dihydro-1H-1,2,4-Triazoline Core Possessing an Acetylated Carbohydrate Appendage: Crystal Structure, Spectroscopy, and Pharmacology

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 12
• Main Authors: Al Maqbali, Anwaar S, Al Rasbi, Nawal K, Zoghaib, Wajdi M, Sivakumar, Nallusamy, Robertson, Craig C, Shongwe, Musa S, Grzegorzek, Norbert, Abdel-Jalil, Raid J
• Format: Journal Article
• Language: English
• Published: 14.06.2024

A new series of chiral 4,5-dihydro-1H-[1,2,4]-triazoline molecules, featuring a β-ᴅ-glucopyranoside appendage, were synthesized via a 1,3-dipolar cycloaddition reaction between various hydrazonyl chlorides and carbohydrate Schiff bases. The isolated enantiopure triazolines (8a-j) were identified thr...